Download e-book for iPad: Computational Modeling in Tissue Engineering: 10 (Studies in by Liesbet Geris

By Liesbet Geris

one of many significant demanding situations in tissue engineering is the interpretation of organic wisdom on advanced telephone and tissue habit right into a predictive and strong engineering approach. getting to know this complexity is an important step in the direction of medical purposes of tissue engineering. This quantity discusses computational modeling instruments that permit learning the organic complexity in a extra quantitative method. extra particularly, computational instruments can assist in:
(i) quantifying and optimizing the tissue engineering product, e.g. via adapting scaffold layout to optimize micro-environmental indications or by means of adapting choice standards to enhance homogeneity of the chosen cellphone population;
(ii) quantifying and optimizing the tissue engineering procedure, e.g. by way of adapting bioreactor layout to enhance caliber and volume of the ultimate product; and
(iii) assessing the effect of the in vivo setting at the habit of the tissue engineering product, e.g. by means of investigating vascular ingrowth.
The e-book offers examples of every of the above pointed out components of computational modeling. The underlying tissue engineering functions will range from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the 1st components, the focus is on (the optimization of) mechanical indications, mass delivery and fluid circulation encountered through the cells in scaffolds and bioreactors in addition to at the optimization of the phone inhabitants itself. within the chapters describing modeling contributions within the 3rd region, the focal point will shift in the direction of the biology, the complicated interactions among biology and the micro-environmental indications and the ways that modeling may be able to help in investigating and gaining knowledge of this complexity. The chapters disguise matters relating to (multiscale/multiphysics) version development, education and validation, but additionally talk about fresh advances in clinical computing options which are had to enforce those versions in addition to new instruments that may be used to experimentally validate the computational results.

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Computational Modeling in Tissue Engineering: 10 (Studies in Mechanobiology, Tissue Engineering and Biomaterials) by Liesbet Geris


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